电针治疗神经病理性疼痛机制研究进展

Advances in Study on Mechanism of Electroacupuncture in Treatment of Neuropathic Pain

神经病理性疼痛是一种临床常见的顽固性慢性疼痛。电针可有效缓解神经病理性疼痛引起的不适,其作用机制可能涉及外周敏化、中枢敏化、下行抑制性调控,其中中枢敏化机制又可细分为脊髓背角神经元相关机制、胶质细胞活化抑制机制、信号通路相关机制以及突触可塑机制。但当前大多数研究的结论尚未得到明确证实,今后可借助基因推敲或相关抑制剂来开展进一步研究以验证作用机制。参考文献34篇。

Neuropathic pain is a common intractable chronic pain in clinic.Electroacupuncture can effectively relieve the symptoms caused by neuropathic pain,which may be related to peripheral sensitization,central sensitization and descending inhibitory modulation.The central sensitization mechanism can be subdivided into neurons in spinal cord-related mechanism,astrocyte activation inhibition mechanism,signal pathway-related mechanism and synaptic plasticity mechanism.The conclusions of most current studies have not been clearly confirmed,and further studies can be carried out with genetic scrutiny or related inhibitors in the future to verify the mechanism.There are a total of 34 references.