左乙拉西坦联合丙戊酸钠治疗小儿癫痫的临床效果

Clinical effect of levetiracetam combined with sodium valproate in the treatment of pediatric epilepsy

目的分析左乙拉西坦联合丙戊酸钠治疗小儿癫痫的临床效果。方法选取2015年1月至2021年1月在我院接受治疗的200例小儿癫痫患儿为研究对象,采用奇偶数法将其分为对照组(n=100,丙戊酸钠)与研究组(n=100,丙戊酸钠+左乙拉西坦)。比较两组的治疗效果。结果治疗3个月后,研究组的癫痫发作次数、发作持续时间、痫样放电导联数、痫样累及导联数优于对照组(P<0.05)。治疗3个月后,研究组的神经元特异性烯醇化酶(NSE)、S100β蛋白、白细胞介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)水平低于对照组(P<0.05)。研究组的不良反应总发生率低于对照组(P<0.05)。结论左乙拉西坦联合丙戊酸钠治疗小儿癫痫的效果显著,有利于减轻神经损伤与炎症反应,且用药安全性高。

Objective To analyze the clinical effect of levetiracetam combined with sodium valproate in the treatment of pediatric epilepsy.Methods A total of 200 children with pediatric epilepsy treated in our hospital from January 2015 to January 2021 were selected as the research objects.The children were divided into control group(n=100,sodium valproate)and study group(n=100,sodium valproate+levetiracetam)by odd and even number method.The therapeutic effects of the two groups were compared.Results After 3 months of treatment,the number of seizures,duration of seizures,number of epileptiform discharge conduction and number of epileptiform involving leads in the study group were better than those in the control group(P<0.05).After 3 months of treatment,the levels of neuron specific enolase(NSE),S100βprotein,interleukin-2(IL-2)and tumor necrosis factor-α(TNF-α)in the study group were lower than those in the control group(P<0.05).The total incidence of adverse reactions in the study group was lower than that in the control group(P<0.05).Conclusion Levetiracetam combined with sodium valproate in the treatment of pediatric epilepsy has a significant effect,which is beneficial to reduce nerve injury and inflammatory response,and has high drug safety.