调经促孕丸联合来曲唑对多囊卵巢综合征不孕患者排卵情况及氧化应激指标的影响

Effects of Tiaojing Cuyun pill combined with letrozole on ovulation and oxidative stress indexes in infertility patients with polycystic ovary syndrome

目的探讨调经促孕丸联合来曲唑对多囊卵巢综合征不孕患者排卵情况及氧化应激指标的影响。方法根据随机数字表法将80例多囊卵巢综合征不孕患者分为对照组和观察组,各组40例。对照组采用常规方案(二甲双胍+炔雌醇环丙孕酮)联合来曲唑治疗,观察组在对照组基础上加调经促孕丸治疗。比较两组的治疗效果。结果治疗后,观察组的睾酮(T)、黄体生成素(LH)、卵泡刺激素(FSH)水平均低于对照组(P<0.05)。治疗后,观察组子宫与卵巢的血流搏动指数(PI)、阻力指数(RI)、收缩期峰值速度(PSV)均低于对照组(P<0.05)。治疗后,观察组的丙二醛(MDA)水平低于对照组,超氧化物歧化酶(SOD)、总抗氧化态(TAS)水平均高于对照组(P<0.05)。观察组治疗后的成熟卵泡大小、成熟卵泡个数,以及随访1年的临床妊娠率、生化妊娠率均优于对照组(P<0.05)。结论调经促孕丸联合来曲唑可改善多囊卵巢综合征不孕患者的激素水平,调节氧化应激指标,改善排卵及妊娠情况。

Objective To investigate the effects of Tiaojing Cuyun pill combined with letrozole on ovulation and oxidative stress indexes in infertility patients with polycystic ovary syndrome.Methods A total of 80 infertility patients with polycystic ovary syndrome were divided into control group and observation group according to the random number table method,with 40 cases in each group.The control group was treated with conventional(metformin+ethingles tradiol and cyproterone acetate)combined with letrozole,and the observation group was treated with Tiaojing Cuyun pill on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the levels of testosterone(T),luteinizing hormone(LH)and follicle-stimulating hormone(FSH)in the observation group were lower than those in the control group(P<0.05).After treatment,the pulsatility index(PI),resistance index(RI)and peak systolic velocity(PSV)of uterus and ovary in the observation group were lower than those in the control group(P<0.05).After treatment,the level of malonelialdehyde(MDA)in the observation group was lower than that in the control group,and the levels of superoxide dismutase(SOD)and total antioxidant state(TAS)were higher than those in the control group(P<0.05).The size and number of mature follicles after treatment,and clinical pregnancy rate and biochemical pregnancy rate during 1-year follow-up in the observation group were better than those in the control group(P<0.05).Conclusion Tiaojing Cuyun pill combined with letrozole can improve the hormone levels of infertility patients with polycystic ovary syndrome,regulate oxidative stress indexes,and improve ovulation and pregnancy.