病毒蛋白调控逆转录元件Ⅰ型长弥散核元件活性的影响及其意义

Effect and significance of viral proteins regulating activity of retroelement long interspersed element 1

型长弥散核元件(long interspersed element-1,LINE-1)是已知人类细胞中唯一具有活性的、可自主转座的逆转录元件(retroelements),与自身免疫性疾病相关,对细胞的抗病毒天然免疫,特别是对细胞干扰素(interferon,IFN)水平起到重要的激活、调控作用。本文阐述了包括人类免疫缺陷病毒(human immunodeficiency virus,HIV)、乙型肝炎病毒(hepatitis B virus,HBV)等病毒的几种非结构蛋白参与调控LINE-1活性的机制。这些机制既保证了病毒基因组的正常表达,又参与调控细胞天然免疫水平,对相关机制的抑制可能为治疗病毒感染引起的疾病提供新的方法。

Long interspersed element-1(LINE-1)is the only known active and autonomously transposable retroelement in human cells,which is related to autoimmune diseases and plays important roles in activating and regulating the antiviral innate immunity of cells,especially the level of interferon(IFN).This paper reviews the mechanisms of several non-structural proteins from human immunodeficiency virus(HIV),hepatitis B virus(HBV)and other viruses participating in the regulation of LINE-1 activity.These mechanisms not only ensure the normal expression of viral genome,but also participate in the cellular innate immunity regulation,the inhibition of which may provide new strategies to develop treatments of diseases caused by viruses.