异吲哚啉衍生物的合成及应用进展

Progress in synthesis and application of isoindoline derivatives

作为一类结构特殊且具有多种用途的重要含氮杂环化合物,异吲哚啉衍生物在医药化工等行业发挥着重要作用,尤其在药物分子设计合成及染料领域有着重要的应用。近年来,异吲哚啉及其衍生物的合成得到了快速的发展,各种异吲哚啉衍生物被合成,尤其是多取代异吲哚啉衍生物的合成及活性研究得到了广泛的关注。本文综述了异吲哚啉衍生物的合成方法,并对其在医药和化工领域的应用进行了介绍。

As a kind of important nitrogen-containing heterocyclic compounds with special structure and various uses,isoindoline derivatives play an important role in pharmaceutical and chemical industries,especially in the fields of design and synthesis of drug molecules and dye.In recent years,the synthesis of isoindoline and its derivatives has developed rapidly.Various isoindoline derivatives have been synthesized,especially the synthesis and activity of polysubstituted isoindoline derivatives have attracted extensive attention.In this paper,the synthetic methods of isoindoline derivatives are reviewed,and their applications in the fields of medicine and chemical industry are introduced.