选择性胶原纤维外脱矿技术在牙本质粘接修复中的应用

Applications of collagen extrafibrillar demineralization in dentin bonding

现有牙本质粘接体系基于酸蚀技术使胶原纤维内外磷灰石同时丧失, 造成过度脱矿, 而粘接剂难以渗入纤维内部, 导致混合层裸露的胶原酶解、树脂降解, 严重危害树脂修复体的临床寿命。选择性胶原纤维外脱矿技术可选择性地将胶原纤维外的磷灰石脱矿, 保留胶原纤维内的磷灰石晶体, 从而有效避免酸蚀技术导致的粘接界面结构完整性损坏, 提高牙本质粘接耐久性。本文就选择性胶原纤维外脱矿技术的作用机制及其在牙本质粘接领域应用的研究进展进行综述。

The existing dentin bonding systems based on acid-etching technique lead to the loss of both extrafibrillar and intrafibrillar minerals from dentin collagen,causing excessive demineralization.Because resin monomers can not infiltrate the intrafibrillar spaces of demineralized collagen matrix,degradation of exposed collagen and resin hydrolysis subsequently occur within the hybrid layer,which seriously jeopardizing the longevity of resin-dentin bonding.Collagen extrafibrillar demineralization can effectively avoid the structural defects within the resin-dentin interface caused by acid-etching technique and improve the durability of resin-dentin bonding,by preserving intrafibrillar minerals and selectively demineralizing extrafibrillar dentin.The mechanism and research progress of collagen extrafibrillar demineralization in dentin bonding are reviewed in the paper.