经支气管冷冻肺活检在肺移植术后并发症诊断中的临床应用

Application of transbronchial cryobiopsy in the diagnosis of postoperative complications after lung transplantation:a report of 6 cases

目的探讨肺移植术后行经支气管冷冻肺活检(transbronchial cryobiopsy,TBCB)的有效性和安全性。方法回顾性分析2021年5—11月,中日友好医院肺移植术后行TBCB患者6例(均为男性,年龄33~67岁)的临床特征、TBCB操作过程、诊疗经过及转归。结果依据TBCB诊断的6例患者中,有2例机化性肺炎,1例急性细胞性排斥反应,1例抗体介导的排异反应,1例闭塞性细支气管炎,1例弥漫性肺泡损伤。在临床诊断明确后调整后续治疗,病情均好转,均未发生与介入操作相关的严重并发症。结论TBCB在肺移植术后并发症诊断中是有价值和相对安全的,但需要严格把握适应证。

Objective To investigate the efficacy and safety of transbronchial cryobiopsy(TBCB)after lung transplantation.Methods The clinical characteristics,TBCB procedure,diagnosis and treatment,and outcomes of lung transplant recipients of 6 patients(all male,aged 33-67 years)with TBCB in China-Japan Friendship Hospital from May to November 2021 were retrospectively analyzed.Results Among the 6 patients diagnosed by TBCB,there were 2 cases of organizing pneumonia,1 acute cellular rejection,1 antibody-mediated rejection,and 1 bronchiolitis obliterans,and 1 diffuse alveolar damage.After the clinical diagnosis was confirmed,the condition improved after adjustment of the treatments followed.There were no serious complications related to the TBCB procedure.Conclusion TBCB is valuable and relatively safe in the diagnosis of complications after lung transplantation,but the indications need to be strictly controlled.