普萘洛尔联合甲巯咪唑治疗轻中度甲状腺功能亢进症的效果

Effect of Propranolol Combined with Methimazole in the Treatment of Mild to Moderate Hyperthyroidism

目的:探讨普萘洛尔联合甲巯咪唑治疗轻中度甲状腺功能亢进症的效果。方法:选取2020年10月-2021年11月哈尔滨市第一医院收治的101例轻中度甲状腺功能亢进症患者作为研究对象。根据随机数字表法将其分为对照组(n=50)和观察组(n=51)。对照组给予甲巯咪唑片,观察组在对照组基础上给予普萘洛尔。观察两组临床疗效,治疗前及治疗3个月后激素水平、骨代谢、心脏功能及甲状腺功能。结果:观察组总有效率(94.12%)高于对照组(80.00%)(P<0.05)。治疗3个月后,观察组促肾上腺皮质激素(ACTH)水平低于对照组,皮质醇(Cor)水平高于对照组(P<0.05)。治疗3个月后,观察组Ⅰ型胶原羧基端肽β特殊序列(β-CTx)、降钙素(CT)与骨钙素(BGP)水平均低于对照组(P<0.05)。治疗3个月后,观察组左心室射血分数(LVEF)高于对照组,心率低于对照组(P<0.05)。治疗3个月后,观察组促甲状腺激素(TSH)水平高于对照组,游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))水平均低于对照组(P<0.05)。结论:普萘洛尔联合甲巯咪唑治疗轻中度甲状腺功能亢进症患者可有效调节激素水平,改善甲状腺功能,缓解骨代谢异常,从而增强心脏功能,提高临床疗效。

Objective:To investigate the effect of Propranolol combined with Methimazole in the treatment of mild to moderate hyperthyroidism.Method:A total of 101 patients with mild to moderate hyperthyroidism admitted to Harbin First Hospital from October 2020 to November 2021 were selected as the research objects.They were divided into control group(n=50)and observation group(n=51)according to the random number table method.The control group was given Methimazole Tablets,and the observation group was given Propranolol on the basis of the control group.The clinical efficacy,hormone level,bone metabolism,cardiac function and thyroid function before and after 3 months of treatment were observed.Result:The total effective rate of the observation group(94.12%)was higher than that of the control group(80.00%)(P<0.05).After 3 months of treatment,the level of adrenocorticotropic hormone(ACTH)in the observation group was lower than that in the control group,and the level of cortisol(Cor)was higher than that in the control group(P<0.05).After 3 months of treatment,the levels of C-terminal peptide of typeⅠcollagenβspecial sequence(β-CTx),calcitonin(CT)and osteocalcin(BGP)in the observation group were lower than those in the control group(P<0.05).After 3 months of treatment,the left ventricular ejection fraction(LVEF)of the observation group was higher than that of the control group,and the heart rate was lower than that of the control group(P<0.05).After 3 months of treatment,the level of thyroid stimulating hormone(TSH)in the observation group was higher than that in the control group,and the levels of free triiodothyronine(FT_(3))and free thyroxine(FT_(4))were lower than those in the control group(P<0.05).Conclusion:Propranolol combined with Methimazole in the treatment of patients with mild to moderate hyperthyroidism can effectively regulate hormone levels,improve thyroid function,relieve abnormal bone metabolism,thereby enhancing cardiac function and improving clinical efficacy.