上海郊区自然人群队列和生物样本库建设

Establishment of Shanghai Suburban Adult Cohort and Biobank

城镇化建设导致人口聚集、环境危险因素暴露风险增加和居民生活方式的改变,人群间健康差异等问题也更加凸显。为了深入研究城镇化快速发展过程中居民慢性非传染性疾病(慢性病)的发病特点及变化趋势,分析环境、生活方式和遗传等因素与主要慢性病的关系,为慢性病的精准防控提供科学依据,复旦大学公共卫生学院依托上海市“高峰学科建设项目”,自2016年4月起在城镇化快速发展的上海市松江、嘉定、闵行和徐汇区启动了“上海郊区自然人群队列和生物样本库”(SSACB)建设工作,招募69116名20~74岁常住居民作为队列成员。队列采用流行病学调查、体格检查和实验室检测等方法收集成员基本资料,采集血、尿等标本建立生物标本库,建立包括队列成员电子医疗病历系统、慢性病管理系统、肿瘤登记系统、传染病报告系统和死亡登记系统在内的区域健康信息共享平台。本文围绕SSACB队列设计理念、建设进程以及今后发展目标进行阐述。

Urbanization has increased the population density and exposure to environmental risk factors,accelerated changes of people's lifestyles and aggravated population health disparities.A general population cohort in eastern China,Shanghai Suburban Adult Cohort and Biobank(SSACB),was established to understand the incidence and prevalence of chronic and non-communicable diseases,and identify environmental,lifestyle,and genetic risk factors in adults(aged 20-74 years old)living in the suburban of Shanghai,where urbanization process is rapid,and provide evidence for the precise prevention and control of chronic diseases.The cohort study was launched by School of Public Health,Fudan University depended on"Discipline Construction Project Shanghai Peak for Public Health and Preventive Medicine".Four districts in Shanghai,i.e.Songjiang,Jiading,Minhang and Xuhui,were selected.A total of 69116 permanent residents aged 20-74 years were recruited.Epidemiological investigation,physical examination and laboratory tests were conducted to collect the basic information of the study subjects.Blood and urine samples were collected from them to establish a biobank.An information platform was established,from which the baseline data of the study subjects in electronic medical record system,chronic disease management system,cancer registry,infectious disease reporting system,and death registry can be shared.This paper introduces the design concept,process and future plan of SSACB.