外泌体源性环状RNA在胃癌中的研究进展

Progress in the study of exosome-derived cyclic RNA in gastric cancer

外泌体是由多种细胞分泌的囊性小泡,其内包含多种物质,如脂质、蛋白质、环状RNA(circRNA)、长链非编码RNA(lncRNA)和微小RNA(miRNA)等物质。而多种外泌体源性环状RNA在胃癌患者血浆中的表达量与正常人血浆中的表达量具有明显差异,直接或间接地影响肿瘤的代谢、转移及预后。较多研究表明,外泌体源性环状RNA在胃癌的发展及向远处转移等事件中起着重要作用,文章重点从外泌体源性环状RNA在胃癌中的诊断、转移及预后等方面的作用进行综述。

Exosomes are vesicles secreted by a variety of cells,which contain a variety of substances,such as lipids,proteins,circular RNA(circRNA),long-chain non-coding RNA(lncRNA)and microRNA(miRNA).However,the expression of multiple exosome-derived cyclic RNA in the plasma of patients with gastric cancer is significantly different from that of normal people,which directly or indirectly affects the metabolism,metastasis and prognosis of tumor.Many studies have shown that exocrine-derived cyclic RNA plays an important role in the development and metastasis of gastric cancer.This article focuses on the role of exocrine-derived cyclic RNA in the diagnosis,metastasis and prognosis of gastric cancer.