术前全身炎症反应指数和纤维蛋白原/清蛋白比值联合分析对乳腺癌患者的意义

The significance of combined preoperative systemic inflammatory response index and fibrinogen/albumin ratio analysis in breast cancer patients

目的探讨术前全身炎症反应指数(SIRI)和纤维蛋白原/清蛋白比值(FAR)联合分析对乳腺癌诊断和预后判断的价值。方法将该院2017-2022年收治的乳腺癌患者共252例纳入研究作为乳腺癌组,另外选取同期体检健康女性206例作为对照组。收集两组人群的一般资料及相关指标的检测结果,计算SIRI和FAR。收集乳腺癌组患者的病理诊断、是否转移、肿瘤最大径、分期、免疫组化等资料。比较乳腺癌组和对照组一般资料及相关检测指标及SIRI、FAR。将所有研究对象根据SIRI和FAR高低进行排序,按四分位数分为4组,观察随着SIRI和FAR的增高,乳腺癌组患者所占比例的变化。利用受试者工作特征(ROC)曲线评估SIRI和FAR用于区分乳腺癌患者和健康人群的诊断效能并获得截断值。根据截断值对乳腺癌患者进行SIRI-FAR评分。分析SIRI-FAR评分与乳腺癌临床病理特征及生存预后的关系。结果乳腺癌组FAR和SIRI高于对照组(P<0.05)。随着SIRI和FAR的增高,乳腺癌组患者所占比例也升高(P<0.05)。ROC曲线分析显示,SIRI、FAR联合分析对乳腺癌的诊断效能高于FAR或SIRI单独使用。高SIRI-FAR评分的患者肿瘤最大径较大,乳腺癌分期较高,易发生淋巴结转移,且患者平均生存时间明显缩短(P<0.05)。结论术前SIRI-FAR评分与乳腺癌患者临床病理参数密切相关,可作为乳腺癌诊疗及预后评估的重要检测指标。

Objective To investigate the value of combined preoperative systemic inflammatory response index(SIRI)and fibrinogen/albumin ratio(FAR)analysis for the diagnosis and prognosis of breast cancer.Methods A total of 252 breast cancer patients admitted to the hospital from 2017-2022 were enrolled in the study as the breast cancer group,in addition to that,206 healthy women who underwent physical examination in the hospital during the same period were enrolled as the control group.General data and test results of related indicators were collected from both groups,and SIRI and FAR were calculated.Data of patients in the breast cancer group such as pathological diagnosis,whether metastasis,maximum tumor diameter,stage,and immunohistochemistry results were collected.The general data and related detection indicators,SIRI and FAR were compared between the breast cancer group and the control group.All subjects were sorted according to the level of SIRI and FAR,and divided into four groups according to the quartile.The changes in the proportion of breast cancer patients were observed with the increase of SIRI and FAR.The receiver operating characteristic(ROC)curve was used to evaluate the diagnostic efficacy of SIRI and FAR in distinguishing breast cancer patients from healthy people and the cut-off values were obtained.The SIRI-FAR score of breast cancer patients was performed according to the cut-off value.The relationship between SIRI-FAR score and clinicopathological characteristics and survival prognosis of breast cancer was analyzed.Results FAR and SIRI were higher in the breast cancer group than those in the control group(P<0.05).The proportion of patients with breast cancer increased with higher SIRI and FAR(P<0.05).ROC curve analysis showed that the diagnostic efficacy of combined SIRI and FAR analysis for breast cancer was higher than that of FAR or SIRI used alone.Patients with high SIRI-FAR scores had larger maximum tumor diameter,higher breast cancer stage,were prone to lymph node metastasis,and the mean survival time of patients was significantly shorter(P<0.05).Conclusion Preoperative SIRI-FAR score is closely related to the clinicopathological parameters of breast cancer patients,which can be used as an important index for the diagnosis,treatment and prognosis evaluation of breast cancer.