脓毒症心肌病的治疗进展

Advances in the treatment of septic cardiomyopathy

脓毒症是以感染导致的全身炎症反应综合征为特征的临床综合征,是诱发多器官功能障碍的重要原因。暂时性、可逆的心肌障碍称为脓毒症心肌病(SCM),是重症监护病房患者死亡的重要原因之一。目前针对脓毒性心肌障碍的治疗以抗感染、液体复苏、升压药物等对症支持治疗为主,但治疗效果不佳。SCM机制的深入研究和医疗技术的不断进步为SCM患者的治疗策略提供了新思路,该文主要从改善心功能药物、抗氧化应激药物、非药物治疗及潜在治疗靶点对SCM的一些新的治疗方案等方面进行综述。

Sepsis is a clinical syndrome characterized by systemic inflammatory response syndrome resulting from infection and is an important cause of inducing multiple organ dysfunction.Temporary and reversible myocardial disorders,called septic cardiomyopathy is one of the important causes of death in intensive care unit patients.At present,the treatment of septic cardiomyopathy is mainly based on anti-infection,fluid resuscitation,vasopressors and other symptomatic and supportive treatment,but the therapeutic effect is poor.The in-depth study of the mechanism of septic cardiomyopathy and the continuous progress of medical technology provide new ideas for the treatment strategies of patients with septic cardiomyopathy.This article mainly reviews some new treatment options for septic cardiomyopathy from drugs to improve cardiac function,anti-oxidative stress drugs,non-drug therapy and potential therapeutic targets.