维生素D与慢性气道疾病相关性的研究进展

Research Progress on Relationship between Vitamin D and Chronic Airway Diseases

慢性气道疾病包括慢性阻塞性肺疾病、支气管哮喘、支气管扩张等,此类疾病难以根治,易反复发作,已成为公共卫生难题的一部分。维生素D是一种简单易测的脂溶性维生素,通过减少促炎细胞因子和增加抗炎细胞因子在调节免疫反应中的潜在作用、改善气道重塑等机制从而在呼吸系统疾病中发挥着重要作用。因此,进一步探讨维生素D与炎症因子之间的相关性,对预测慢性气道疾病患者的病情及预后具有一定的参考价值,为临床综合干预能提供更多的理论依据。

Chronic airway diseases include chronic obstructive pulmonary disease,bronchial asthma,bronchiectasis and other diseases,which are difficult to cure and recurrent,and have become part of the public health problem.Vitamin D is a simple and measurable fat-soluble vitamin that plays an important role in respiratory diseases by reducing pro-inflammatory cytokines and increasing the potential role of anti-inflammatory cytokines in regulating immune responses and improving mechanisms such as airway remodeling.Therefore,further exploring the correlation between vitamin D and inflammatory factors has certain reference value for predicting the condition and prognosis of patients with chronic airway disease,and can provide more theoretical basis for clinical comprehensive intervention.