红细胞分布宽度对原发性高血压的预测价值

Predictive value of red blood cell distribution width for essential hypertension

目的探讨红细胞分布宽度(RDW)在原发性高血压(EH)人群中的分布特点及其与EH严重程度的关系,评价RDW对EH的诊断价值。方法选择2019年7月至2021年7月在扬州大学附属医院心血管内科住院初诊的EH患者300例,对照组为同期健康体检者105例,同时依据指南将EH患者分为高血压1级组、高血压2级组和高血压3级组,各100例。比较两组及EH各亚组间的RDW水平,分析RDW与EH的相关性及EH的独立危险因素。结果EH组RDW水平显著高于对照组(P<0.01),RDW在EH各亚组水平均高于正常对照组(P<0.05)。多因素logistic回归分析显示,除三酰甘油、低密度脂蛋白胆固醇、纤维蛋白原、吸烟、年龄等因素外,RDW(OR=5.786,95%CI:2.998~11.165,P<0.01)也是EH的独立危险因素。ROC曲线分析显示,RDW诊断EH的界点值为11.95%(特异度为58%,敏感度为83%)。结论RDW与EH及其严重程度有关,是EH的独立危险因素,RDW可为EH的预测提供一定依据。

Objective To investigate the distribution characteristics of red blood cell distribution width(RDW)in the population with essential hypertension(EH)and its relationship with the severity of EH to evaluate the diagnostic value of RDW for EH.Methods A total of 300 patients with newly diagnosed EH hospitalized in the Affiliated Hospital of Yangzhou University from July 2019 to July 2021 were selected as subjects(EH group),and 105 of healthy physical examination personnel in the same period were included in the control group.According to the diagnostic criteria of hypertension,EH patients were divided into hypertension grade 1 group,hypertension grade 2 group and hypertension grade 3 group(n=100,each).The RDW levels were compared between two groups and among the subgroups to analyze the correlation between RDW and EH and the independent risk factors for EH.Results The level of RDW in EH group(including three subgroups)was significantly higher than that in control group(P<0.05).Multivariate logistic regression analysis showed that RDW(OR=5.786,95%CI:2.998-11.165,P<0.01)was also an independent risk factor for EH in addition to triacylglycerol,low density lipoprotein cholesterol,fibrinogen,smoking,age and other factors.The ROC curve analysis showed that the cut-off value of RDW for EH was 11.95%,with a specificity of 58%and sensitivity of 83%.Conclusion RDW is correlated to EH and its severity,and is the independent risk factor for EH,which can provide certain basis for the predicition of EH.