樟柳碱联合多点扫描模式激光对非增生型糖尿病视网膜病变的疗效及血清Fractalkine、Apelin的影响

Effect of anisodine combined with multi-point scanning mode laser on non-proliferative diabetic retinopathy and the influence of serum Fractalkine and Apelin

目的探讨樟柳碱联合多点扫描模式激光治疗非增生型糖尿病视网膜病变(NPDR)患者的疗效及对患者血清炎性因子、Fractalkine(FKN)和爱帕琳肽(Apelin)水平的影响。方法选取2019年6月至2021年2月西部战区空军医院收治的NPDR患者94例作为研究对象,随机分为观察组(n=47)和对照组(n=47)。对照组采用多点扫描模式激光治疗,观察组加用复方樟柳碱,均治疗2周。观察两组患者的疗效、不良反应,治疗前后的最佳矫正视力、黄斑区中心视网膜厚度(CMT)、血清炎性因子、FKN和Apelin水平。结果治疗后,观察组的总有效率(91.5%)高于对照组(74.5%),差异有统计学意义(χ^(2)=4.821,P<0.05)。两组患者的BCVA、CMT、白细胞介素(IL)-6、IL-10x0E䥺SymbolbA@0x0F、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF)-α、FKN和Apelin水平均较治疗前下降,且观察组低于对照组(P<0.05)。治疗期间,两组患者皮疹、穿刺部位疼痛、恶心等不良反应总发生率差异无统计学意义(P>0.05)。结论采用樟柳碱联合多点扫描模式激光治疗NPDR具有较好的疗效,并可降低血清炎性因子、Fractalkine和Apelin水平。

Objective To investigate the effects of anisodine combined with multi-point scanning laser treatment on patients with non-proliferative diabetic retinopathy(NPDR),and the influence of serum inflammatory factors,Fractalkine(FKN)and Apelin levels.Methods Ninety-four patients with NPDR admitted in Air Force Hospital of Western Theater Command from June 2019 to February 2021 were selected as the research objects,and they were randomly divided into observation group(n=47)and control group(n=47).Multi-point mode laser treatment was used for the control group,and compound camphorine was added to the observation group on the basis of the control group,both for 2 weeks.The efficacy,adverse reactions,best corrected visual acuity,central macular thickness(CMT),inflammatory factors,FKN and Apelin levels in serum were observed before and after treatment.Results After treatment,the total effective rate(91.5%)of the observation group was significantly higher than that of the control group(74.5%),reaching a statistical difference(χ^(2)=4.821,P<0.05).BCVA,CMT,interleukin(IL)-6,IL-1β,high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor(TNF)-α、FKN and Apelin levels in two groups decreased compared with before treatment,and above indexes levels in observation group were lower than those in control group(P<0.05).During the treatment period,there was no significant difference in the incidence of skin rash,puncture site pain,nausea and other adverse reactions between the two groups(P>0.05).Conclusion The combination of anisodine and multi-point scanning mode laser is effective in the treatment of NPDR,and can reduce the levels of serum inflammatory factors,Fractalkine and Apelin.