摘要
3-羟基-3-甲基戊二酸单酰辅酶A(HMG-CoA)还原酶抑制剂,通常称为他汀类药物,因其降低内源性胆固醇的确切作用而被广泛应用于心脑血管疾病、高脂血症等的治疗。除了对胆固醇合成的抑制作用以外,他汀类药物还具有促凋亡、抗血管生成和免疫调节作用,可以有效阻止肿瘤细胞生长。本文主要就他汀类药物在肾癌防治中的研究进展及争议等进行综述。
3-hydroxy-3-methylglutaryl coenzyme-A(HMG-CoA)reductase inhibitors,commonly known as statins,are widely used in the treatment of hyperlipidemia and cardio-vascular diseases due to their precise role in reducing endogenous cholesterol.In addition to the inhibition of cholesterol synthesis,statins also have the effects of promoting apoptosis,anti-angiogenesis and immune regulation,which can effectively prevent the growth of tumor cells.This paper reviews the research progress and controversy of statins in the prevention and treatment of renal cell carcinoma.
作者
姚榆
袁艺
张桂铭
YAO Yu;YUAN Yi;ZHANG Gui-ming(Department of Urology,The Affiliated Hospital of Qingdao University,Qingdao,Shandong 266003,China)
出处
《中国临床研究》
CAS
2023年第1期152-155,共4页
Chinese Journal of Clinical Research
基金
山东省自然科学基金(ZR2021MH354)
青岛市医药卫生科研计划(2021-WJZD170)。
关键词
他汀类药物
肿瘤
肾细胞癌
凋亡
胆固醇
心脑血管疾病
高脂血症
Statins
Tumor
Renal cell carcinoma
Apoptosis
Cholesterol
Cardio-cerebrovascular diseae
Hyperlipidemia
