基于磁泳的微流控分离技术研究进展

Research advances of microfluidic separation technology based on magnetophoresis

微粒或细胞的分离是微流控芯片的一项重要应用。微流控芯片与磁泳结合的分离技术以其低成本、高选择性和高生物相容性等优势为生化分析、临床医学和环境工程等领域开辟了新的发展方向。本综述介绍了近年来微流控分离技术中操控微粒或细胞的外力机制研究进展,分析了影响磁泳分离的主要因素,评述了基于磁泳原理的微流控分离技术中的间歇式分离方法和连续流动式分离方法及其应用。最后,对磁泳微流控分离技术的发展方向进行了展望。

Separation of microparticles or cells is one of the most important applications of microfluidic chips.Combining magnetophoresis with microfluidic chip has opened a new development direction for biochemical analysis,clinical medicine,environmental engineering,and other related fields owing to its remarkable advantages such as low cost,high selectivity,and high biocompatibility.This paper reviewed recent progress in external force mechanisms underlying separation and controlling microparticles or cells,analyzed the main factors dominating magnetophoretic separation,and discussed the intermittent separation method and continuous flow separation method using magnetophoresis-based microfluidic separation and their applications.Finally,the developing trends of microfluidic separation technology based on magnetophoresis was prospected.