氧化应激影响膀胱梗阻性疾病分子机制的研究进展

Research progress in molecular mechanism of oxidative stress on bladder outlet obstruction

各种原因引起的膀胱出口梗阻(BOO)是导致膀胱组织变化的重要原因,包括膀胱生理功能和结构的改变。以往认为引起膀胱一系列变化的原因主要是膀胱内压的增高导致的机械压力触发一系列分子通路的激活,最终引起膀胱功能和结构的改变。近年来的研究发现膀胱血流供应不足和缺氧等引起的氧化应激在膀胱功能和结构的改变中起到重要的作用,BOO动物模型中氧化应激的生物标志物的变化来支持了这一联系。本文主要介绍氧化应激在膀胱出口梗阻后的一系列进展中引起膀胱功能改变的一系列分子机制,系统的认识氧化应激在BOO中的作用,为后续的研究提供线索。

Bladder outlet obstruction(BOO)are important causes of changes in bladder tissue,including changes in physiological function and bladder structure.In the past,it was believed that the main reason for the changes in the bladder was that the mechanical pressure triggered the activation of a series of molecular pathways due to the increase of bladder internal pressure,which ultimately led to changes in bladder function and structure.Recent studies have found that oxidative stress caused by insufficient bladder blood supply and hypoxia plays an important role in the change of bladder function and structure,and the link is supported by the change of biomarkers of oxidative stress in BOO animal model.This article mainly introduces a series of molecular mechanisms that oxidative stress causes changes in bladder function in a series of developments after BOO,and systematically recognizes the role of oxidative stress in BOO,providing clues for subsequent research.