米诺环素对动脉瘤性蛛网膜下腔出血后神经保护作用的研究进展

Neuroprotective effect of minocycline on aneurysmal subarachnoid hemorrhage

米诺环素是四环素类广谱抗菌药,临床上用于治疗常见敏感病原菌引起的感染。近期研究发现米诺环素对动脉瘤性蛛网膜下腔出血后损伤体现出神经保护作用。米诺环素主要通过抗炎、抗凋亡、抑制基质金属蛋白酶-9等抗菌外作用减轻动脉瘤性蛛网膜下腔出血引发的早期脑损伤和迟发性脑血,且由于其良好的安全性和耐受性,对动脉瘤性蛛网膜下腔出血的辅助治疗具有一定潜力。本文就米诺环素对动脉瘤性蛛网膜下腔出血的神经保护作用及其可能机制进行综述,为后续深入研究及设计开展临床试验奠定基础。

Minocycline is a broad-spectrum tetracycline antimicrobial agent,which is used to treat infections caused by common sensitive pathogens.Recent studies have found that minocycline has a neuroprotective effect on the injury after aneurysm subarachnoid hemorrhage.Minocycline alleviates early brain injury and delayed cerebral ischemia caused by aneurysmal subarachnoid hemorrhage mainly through non-anti-infective effect,such as antiinflammatory,anti-apoptosis,and inhibition of matrix metalloproteinase-9.In addition,because of its sound safety and tolerance,it has a certain potential for adjuvant therapy of aneurysmal subarachnoid hemorrhage.In this paper,we mainly review the neuroprotective effect and possible mechanisms of minocycline on aneurysmal subarachnoid hemorrhage,which lays a foundation for further research and design of clinical trials.