摘要
生理药动学(physiologically based pharmacokinetic,PBPK)模型是一种模拟药物在人或动物体内吸收、分布、代谢和排泄过程的数学模型,集成了药物的理化和系统(生理)信息,能描述药物在靶组织器官中的经时变化,用于药物研究的各个阶段。本文将综述PBPK模型在抗感染药物研发及临床评价中的应用,为抗感染药物研发及临床合理应用提供参考。
Used in the different stages of drug research,the physiologically based pharmacokinetic(PBPK)model is a mathematical model that simulates the absorption,distribution,metabolism and excretion of drugs in humans or animals,which can describe the changes in the target tissues and organs over time.This article will review the applications of the PBPK model in the development and clinical evaluation of anti-infective drugs,and provide references for the development of anti-infective drugs and rational clinical application.
作者
董柳含
许小菊
王瑾
蔡芸
Dong Liu-han;Xu Xiao-ju;Wang Jin;Cai Yun(Center of Medicine Clinical Research,Chinese PLA General Hospital,Beijing 100853;Medical School of Chinese PLA,Beijing 100853;ChongQing Medical University,Chongqing 400016)
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2022年第10期1013-1019,共7页
Chinese Journal of Antibiotics
基金
国家自然科学基金(No.82073894)
解放军总医院“国家杰出青年科学基金”培育专项(No.2020-JQPY-004)。
关键词
生理药动学模型
抗感染药物
新药研发
合理用药
Physiologically based pharmacokinetic model
Anti-infective drug
Drug development
Rational drug-use
