肝豆灵联合多巴丝肼治疗湿热内蕴型肝豆状核变性伴震颤的临床观察

Clinical Observation of Gandouling Tablet Combined with Levodopa and Benserazide Tablet in the Treatment of Damp-Heat Intrinsic Wilson’s Disease with Tremor

目的 观察肝豆灵联合多巴丝肼治疗湿热内蕴型肝豆状核变性(wilson’s disease, WD)伴震颤的临床疗效和安全性。方法 选取WD伴震颤患者,采用随机数字法将年龄在20~50岁之间的30例湿热内蕴型WD伴震颤患者分为对照组15例和治疗组15例。在常规排铜治疗上,对照组给予多巴丝肼口服,治疗组在对照组方案基础上加用肝豆灵口服,2组总疗程为4周,治疗后对比2组患者的临床疗效。观察治疗前后统一Wilson分级量表(UWDRS)、中医证候积分、血常规和肝肾功能指标。结果 治疗后统一Wilson分级量表(UWDRS)、中医证候积分均低于治疗前(P<0.05)。组间比较,治疗组优于对照组(P<0.05);治疗后组间比较提示治疗组在治疗后总有效率为86.67%,对照组为66.67%,治疗组优于对照组(P<0.05);2组不良反应比较,差异无统计学意义(P<0.05)。结论 肝豆灵联合多巴丝肼治疗湿热内蕴型WD伴震颤患者能提高临床疗效和改善中医证候,且疗效优于多巴丝肼单用。

Objective: To observe the clinical efficacy and safety of Gandouling tablet combined with levodopa and benserazide tablet in the treatment of damp-heat intrinsic wilson’s disease(WD) with tremor. Methods: The WD patients with tremor were selected, and 30 WD patients aged between 20 and 50 years old were randomly divided into a control group(15 cases) and a treatment group(15 cases). Based on the routine copper discharge treatment, the control group was given oral levodopa and benserazide tablets, and the treatment group was given oral Gandouling tablets on the basis of the control group. The total course of treatment was 4 weeks, and the clinical efficacy of the two groups was compared after treatment. The unified Wilson Scale(UWDRS), TCM syndrome score, blood routine and liver and kidney function indexes were observed before and after treatment. Results: After treatment, the unified Wilson Scale(UWDRS) and TCM syndrome scores were lower than those of the prior treatment(P<0.05). The treatment group was better than the control group(P<0.05). The total effective rate was 86.67% in the treatment group and 66.67% in the control group(P<0.05). There was no statistically significant difference in adverse reactions between the two groups(P>0.05). Conclusion: Gandouling tablet combined with levodopa and benserazide tablet can improve clinical efficacy and TCM syndromes in the treatment of damp-heat intrinsic WD patients with tremor, and the efficacy is better than levodopa and benserazide tablet alone.