近10年溃疡性结肠炎发病机制研究的可视化分析

Visualized analysis of the research on the pathogenesis of ulcerative colitis in the past 10 years

目的基于近10年溃疡性结肠炎发病机制的相关文献,探索该领域的研究现状、研究热点及前沿趋势。方法检索Web of Science核心合集数据库中2011年至2021年关于溃疡性结肠炎发病机制的文献。运用Citespace 5.8.R3软件对国家、机构进行合作分析,对作者进行合作及共被引分析,对学科进行共现分析,对期刊进行共被引、双图叠加分析,对关键词进行共现、聚类及突现分析,绘制可视化知识图谱。结果共纳入文献1425篇,总体发文量处于上升趋势,中国发文量最高,美国与他国的合作性最强;上海中医药大学是发文最多的机构;发文量最多的是ASHWIN N ANANTHAKRISHNAN,共被引频次最高的作者是DANESE S;研究学科以胃肠肝病学为主;共被引次数最多的期刊是GASTROENTEROLOGY;关键词聚类得到10个聚类,涉及免疫、炎症、菌群、基因遗传等,关键词突现分析提示肠道菌群、核因子κB等为前沿热点。结论近10年溃疡性结肠炎发病机制方面的研究越来越受到关注,目前认为UC的发病是基因、炎症、免疫、微生物群以及环境因素等共同作用的结果。可视化分析展示了该领域的研究现状、热点及前沿趋势,为日后的研究提供一定的参考。

Objective To investi gate the research status,hotspots and frontier trends in the field of pathogenesis of ulcerative colitis based on the related literature in the past 10 years.Methods The Web of Science Core Collection database was searched for literature on the pathogenesis of ulcerative colitis from 2011 to 2021.Use Citespace 5.8.R3 software to analyze the cooperation of countries and institutions,analyze the cooperation and co-citation of authors,conduct co-occurrence analysis of disciplines,conduct co-citation and double-image overlay analysis of journals,and conduct co-occurrence,clustering and emergent analysis of keywords,drawing a visual knowledge graph.Results A total of 1425 papers were included,and the overall number of papers was on the rise.China had the highest number of papers,and the United States had the strongest cooperation with other countries.Shanghai University of Traditional Chinese Medicine was the institution that published the most papers.ASHWIN N ANANTHAKRISHNAN had the most papers.The author with the highest citation frequency is DANESE S.The research subject is mainly gastroenterology and hepatology and the the most co-citations journal is GASTROENTEROLOGY.Ten clusters are obtained by keyword clustering,involving immunity,inflammation,microbiota,genetic inheritance,etc.Keyword emergent analysis indicated that gut microbiota and nfκB are frontier hotspots.Conclusion In the past 10 years,more and more attention has been paid to the research on the pathogenesis of ulcerative colitis.Currently,the pathogenesis of UC is believed to be the result of the combined effects of genes,inflammation,immunity,microbiota,and environmental factors.The knowledge graph visualization analysis shows the research status,hotspots and frontier trends in this field,and provides a certain reference for future research.