摘要
Although metal-based chemical agents have demonstrated promising bacteriostatic effects in phototherapy,their short excitation/emission wavelengths and inadequate phototherapy efficiencies make their application in vivo difficult.We therefore synthesized a novel Pt(Ⅱ)metallacycle(Pt1110)that can be activated with a 980 nm laser for photodiagnosis/treatment in deep tissue.We found that Pt1110 significantly improved photothermal conversion(95%improvement)and ^(1)O_(2) generation(ΦΔ75%increase)compared to the ligand itself 1 and was well capable of light-induced sterilization under safe laser irradiation(0.72 W/cm^(2)).In addition,Pt1110 has little to no toxicity to cells.After incorporated into liposome,Pt1110 NPs was effective in wound healing in infection and keratitis models upon laser irradiation,which was accurately observed by NIR-Ⅱfluorescence imaging.This novel metal-coordinated supramolecular material has a potential to become a universal platform for phototherapy in deep tissue.
基金
supported by National Natural Science Foundation of China(22022404,22074050,21904103)
the Fundamental Research Funds for the Central Universities(CCNU22QN007)
the Open Research Fund of State Key Laboratory of Chemo/Biosensing and Chemometrics(2021005)
the Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules Hubei University(KLSAOFM2111)
the Opening Project of Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education,Jianghan University(JDGD-202209)
the Open Project Program of Key Laboratory for Analytical Science of Food Safety and Biology,Ministry of Education(FS2202)
supported by the CRI project of National Research Foundation of Republic of Korea(2018R1A3B1052702,JSK)。
