PET成像在妇科恶性肿瘤诊疗中的应用进展

Advances in the application of positron emission tomography in the diagnosis and treatment of gynecological malignancies

正电子发射断层扫描(PET)已被用于妇科恶性肿瘤诊断,在检测转移性病变和局部复发诊断及评估治疗效果方面均优于常规成像方法。与肿瘤活检材料的体外评估相比,PET成像具有能够测量体内肿瘤行为、表征整个肿瘤负荷以及捕获肿瘤表型异质性的优势。PET成像通过整合代谢特征的解剖和功能数据,提供有关分期、复发的精准信息,从而实现对妇科恶性肿瘤的高质量评估。本文对PET成像在宫颈癌、卵巢癌、子宫内膜癌诊疗中的应用进展进行综述。

Positron emission tomography(PET)has been used for the diagnosis of gynecological malignancies and is superior to conventional imaging tools in detecting metastatic lesions,diagnosing local recurrence,and evaluating treatment outcome.Compared with the in vitro assessment of tumor biopsy materials,PET imaging has advantages in measuring in vivo tumor behaviors,characterizing overall tumor burden,and capturing the phenotypic heterogeneity of tumors.PET imaging provides precision data on tumor staging and recurrence through integrating the anatomic and functional data of metabolic features,thereby achieving the high-quality assessment of gynecological malignancies.This article reviews the advances in the application of PET imaging in the diagnosis and treatment of cervical cancer,ovarian cancer,and endometrial carcinoma.