实时荧光人乳头瘤病毒检测和液基薄层细胞学检查对宫颈病变的预测价值

Predictive Value of Real-Time Fluorescent Human Papillomavirus Detection and Thinprep Cytology Test in Cervical Lesions

目的:分析实时荧光人乳头瘤病毒(HPV)检测和液基薄层细胞学检查(TCT)对宫颈病变的预测价值。方法:收集2020年1月~2021年6月行实时荧光HPV检测和TCT患者,其中有一项或两项阳性者行阴道镜活检病例300例。以病理诊断为金标准,分析两种方法敏感性、特异性和阳性预测值,并对宫颈病变感染HPV型别进行分析。结果:300例中宫颈病变患者89例,实时荧光HPV检测敏感性96.63%、特异性4.27%、阳性预测值29.86%;TCT敏感性53.93%、特异性83.89%、阳性预测值58.54%。两种方法差异比较均具有统计学意义(P<0.05)。宫颈病变HPV 16和52型检出率最高。结论:两种检测方法各有优势,二者结合可以弥补自身不足,避免漏诊。

Objective: To analyze the predictive value of real-time fluorescent human papillomavirus(HPV) detection and thinprep cytology test(TCT) in cervical lesions. Methods: From January 2020 to June 2021, patients who underwent real-time fluorescent HPV detection and TCT were collected.300 cases of colposcopy biopsy were performed if one or both of them were positive. Taking pathological diagnosis as the gold standard, the sensitivity, specificity and positive prediction of the two methods were analyzed. The HPV types of cervical lesions were analyzed. Results: Among the 300 cases, 89 cases were patients with cervical lesions. The sensitivity, specificity and positive prediction of real-time fluorescent HPV detection were 96.63%, 4.27% and 29.86%. The sensitivity, specificity and positive prediction of TCT was 53.93%, 83.89% and 58.54%. There were significant differences between the two methods(P<0.05). HPV 16 and 52 had the highest detection rates. Conclusion: Both methods have their own advantages. The combination can make up for their shortcomings and avoid missed diagnosis.