IL-17A三个多态性位点与泉州地区人群类风湿关节炎相关性研究

Correlation between IL-17A gene polymorphism and rheumatoid arthritis in Quanzhou region

目的 探讨白介素-17A(IL-17A)的三个多态性位点rs3819024A/G、rs3819025G/A和rs4711998A/G基因多态性与福建泉州地区人群类风湿关节炎(RA)易感性的相关性。方法 采用病例-对照研究法,选择确诊RA患者207例和252名健康对照者为研究对象,应用全血三引物扩增法对RA相关的三个SNP位点进行基因分型并对数据进行统计学分析。结果 两组SNP位点rs3819025G/A等位基因A和G比较差异具有统计学意义(P<0.05);两组SNP位点rs3819024A/G和rs4711998A/G比较,各基因型和等位基因频率分布差异无统计学意义(P>0.05)。结论 IL-17A SNP位点rs3819024A/G和rs4711998A/G与泉州地区人群RA发病无相关性,IL-17A SNP位点rs3819025G/A与泉州地区人群RA发病有相关性。

Objective To investigate the association of interleukin-17A(IL-17A) rs3819024A/G, rs3819025G/A and rs4711998A/G gene polymorphism with susceptibility to rheumatoid arthritis(RA) in Quanzhou region, Fujian.Methods A case-control study was used to collect 207 RA patients and 252 healthy people. Whole blood threeprimer amplification was used to genotype three RA-related SNP loci, and the date were statistically analyzed.Results Compared with the normal control group, SNP rs3819025G/A of the RA group had significant differences in the distribution frequency of each genotype and allele(P<0.05). Compared with the normal control group, there was no significant difference in the distribution frequency of SNP rs3819024A/G and rs4711998A/G of each genotype and allele(P>0.05). Conclusion The IL-17A SNP loci rs3819024A/G and rs4711998A/G have no correlation with the incidence of RA in Quanzhou region, while the IL-17A SNP loci rs3819025G/A is associated with the RA incidence in Quanzhou region.