肥胖致高血压机制的研究进展

Research progress of obesity-induced hypertension mechanism

高血压是一种常见的慢性疾病,近些年来,由于患病率大幅度上升,已成为世界范围内日益严重的公共卫生问题之一。基于高血压发生的病理生理过程尚未清楚,对其发病机制的研究受到广泛的重视。研究显示高血压疾病与肥胖有着密切的关系,并且肥胖所致高血压的发病率日益增加,肥胖致高血压发生的机制研究是肥胖人群预防和治疗高血压的重要依据,本研究对肥胖与高血压的关系和机制进行了系统总结回顾,显示肥胖人群其高血压患病率高于正常体质指数人群,揭示肥胖人群体内多余脂肪组织可以通过激活交感神经系统、肾素-血管紧张素-醛固酮系统,或通过介导氧化应激和炎性反应从而影响高血压疾病发生发展过程,可为高血压临床治疗提供新思路。

Hypertension is a common chronic disease. In recent years, due to the significant increase in prevalence, it has become one of the increasingly serious public health problems worldwide. The pathophysiological process of hypertension is still unclear, and the study of its pathogenesis has received extensive attention. Studies show that hypertension is closely related to obesity, and the incidence of obesity-induced hypertension is increasing. The study on the mechanism of obesity-induced hypertension is an important basis for the prevention and treatment of hypertension in obese people.This study intends to systematically summarize and review the relationship and mechanism between obesity and hypertension. It is suggested that the prevalence of hypertension in obese population is higher than that in normal body mass index population, revealing that excess adipose tissue in obese people can activate the sympathetic nervous system, renin-angiotensin-aldosterone system, or through mediating oxidative stress and inflammatory response to affect the occurrence and development of hypertension. It will provide new ideas for clinical treatment of hypertension.