胞外囊泡在银屑病中的研究进展

Update of extracellular vesicles in psoriasis

银屑病是一种常见的慢性复发性炎症性皮肤病,以角质形成细胞过度增殖和分化异常及炎性细胞浸润为主要病理特点。胞外囊泡(extracellular vesicles,EVs)是由多种细胞分泌的一类脂质双层包裹的纳米级囊泡,可作为细胞间通讯和物质传输的载体,调控靶细胞的生理或病理反应。本文就EVs在银屑病的发病机制与应用中的研究进展进行综述。

Psoriasis is a common chronic recurrent inflammatory skin disease,characterized by excessive proliferation and abnormal differentiation of keratinocytes as well as infiltration of inflammatory cells.Extracellular vesicles(EVs)are a kind of lipid bilayer encapsulated nanoscale vesicles secreted by many kinds of cells,which act as carriers of intercellular communication and substance transmission to regulate the physiological or pathological responses of target cells.The update of EVs in the pathogenesis and application of psoriasis is reviewed in this paper.