摘要
抗菌肽是先天免疫系统的重要组成部分,LL-37是已知唯一在人体中表达的抗菌肽。LL-37除了具有抗结核活性和免疫调节等生物学功能外,还可能是活动性结核的重要标识。本文着重就结核分枝杆菌感染调控LL-37表达机制、LL-37在结核分枝杆菌感染过程中的免疫防御以及免疫调节功能等方面进行阐述。另外,讨论了LL-37在结核病诊断、治疗中的应用潜力,以期为结核病预防和控制工作提供新的思路。
Antibacterial peptides are an important part of the innate immune system,and LL-37 is the only antimicrobial peptide known to be expressed in humans.LL-37 has anti-tuberculosis activity and immunomodulatory functions,and it has been found to be a diagnostic marker for tuberculosis.This research focused on the mechanism of regulation of LL-37 expression by Mycobacterium tuberculosis infection,and the immune defense and immunomodulatory functions of LL-37 in the process of Mycobacterium tuberculosis infection.In addition,potential applications of LL-37 in the diagnosis and treatment of tuberculosis are discussed to provide new ideas for tuberculosis prevention and control.
作者
张志芳
徐咏梅
万珈旭
高妍
陈祥
徐正中
焦新安
ZHANG Zhi-fang;XU Yong-mei;WAN Jia-xu;GAO Yan;CHEN Xiang;XU Zheng-zhong;JIAO Xin-an(Jiangsu Key Lab of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses,Yangzhou University,Yangzhou 225009,China;Key Laboratory of Prevention and Control of Biological Hazard Factors(Animal Origin)for Agrifood Safety and Quality,Ministry of Agriculture and Rural Affairs,Yangzhou University,Yangzhou 225009,China)
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2023年第1期78-83,共6页
Chinese Journal of Zoonoses
基金
国家重点研发计划项目(No.2021YFD1800403)
江苏省自然科学基金(No.BK20201432)
江苏省农业科技自主创新资金项目[No.CX(21)1004]
江苏省重点研发计划(现代农业)(No.BE2021331)
优势学科建设工程项目(PAPD)联合资助。
关键词
结核病
结核分枝杆菌
免疫调控
抗菌肽
LL-37
tuberculosis
Mycobacterium tuberculosis
immunoregulation
antimicrobial peptides
LL-37
