血清学指标联合检测在急性肺栓塞诊断中的预警价值

Early warning value of combined detection of serological indicators in the diagnosis of acute pulmonary embolism

目的探讨血清学指标联合检测对急性肺栓塞诊断的预警价值。方法回顾性分析确诊的92例急性肺栓塞患者及59例非急性肺栓塞患者的一般资料、D-二聚体(D-D)、乳酸脱氢酶(LDH)、平均血小板体积(MPV)、中性粒细胞与淋巴细胞比值(NLR)等数值,并对2组间差异显著的血清学指标单独及联合行ROC曲线分析,探究其对急性肺栓塞诊断的预警价值。结果2组间血清学指标D-D、LDH、羟丁酸脱氢酶(HBDH)、MPV、NLR水平比较差异有统计学意义(P<0.05),D-D和MPV联合检测时敏感性为53.26%,特异性为84.75%;D-D、LDH、HBDH、NLR联合检测时敏感性为59.78%,特异性为86.44%。结论D-D、MPV联合检测及D-D、LDH、HBDH、NLR联合检测对诊断急性肺栓塞具有较高的特异性,与D-二聚体诊断急性肺栓塞的高敏感性结合,可作为诊断急性肺栓塞的预警体系。

Objective To explore the early warning value of combined detection of serological indicators in the diagnosis of acute pulmonary embolism.Methods The general data,D-dimer(D-D),lactate dehydrogenase(LDH),mean platelet volume(MPV),neutrophils and The cell-to-lymphocyte ratio(NLR)and other values were analyzed,and ROC curve analysis was performed on serological indicators with significant differences between the two groups alone and in combination to explore their early warning value in the diagnosis of acute pulmonary embolism.Results Serological indexes D-D,LDH,hydroxybutyrate dehydrogenase(LBDH),MPV,and NLR levels were significantly different between the two groups(P<0.05).The sensitivity of combined detection of D-D and MPV was 53.26%,and the specificity was 53.26%.The sensitivity was 59.78%and the specificity was 86.44%for combined detection of D-D,LDH,LBDH and NLR.Conclusion The combined detection of D-D,MPV and combined detection of D-D,LDH,LBDH and NLR have good early warning value for diagnosis of acute pulmonary embolism.