摘要
B族链球菌(group B Streptococcus,GBS)可导致围产期孕产妇严重感染、死产及早产,也是引起新生儿感染性疾病的主要病原体。GBS在孕产妇阴道定植后发生上行感染是主要传播途径。GBS由无症状定植发展为侵袭性感染的致病机制主要集中在毒力因子、双组分信号转导系统的调控及对宿主的免疫逃逸等方面。本文对近年来围产期GBS感染的致病机制研究进展进行综述,为GBS疫苗开发和寻找新的治疗手段提供理论基础。
Group B Streptococcus(GBS)is a major cause of severe perinatal infection,stillbirth,premature delivery,and neonatal infectious diseases.Ascending infection after vaginal colonization is the main route of prenatal GBS transmission.The pathogenic mechanism of GBS from asymptomatic colonization to invasive infection mainly relates to virulence factors,the regulation of two-component systems and immune escape.This paper reviews progress in pathogenic mechanism of perinatal GBS infection in recent years,aiming to provide a theoretical basis for the development of vaccines and new treatment approaches against GBS.
作者
祝垚
陈超
林新祝
Zhu Yao;Chen Chao;Lin Xinzhu(Department of Neonatology(Xiamen Key Laboratory of Perinatal-Neonatal Infection),Women and Children's Hospital,School of Medicine,Xiamen University(Xiamen Maternal and Child Care Hospital),Xiamen 361003,China;Department of Neonatology,Children's Hospital of Fudan University,Shanghai 201102,China)
出处
《中华围产医学杂志》
CAS
CSCD
北大核心
2022年第12期919-924,共6页
Chinese Journal of Perinatal Medicine
基金
厦门市医疗卫生指导性项目(3502Z20199077)。
关键词
无乳链球菌
链球菌感染
传染性疾病传播
垂直
妊娠并发症
感染性
毒力因子类
免疫逃避
Streptococcus agalactiae
Streptococcal infections
Infectious disease transmission,vertical
Pregnancy complications,infectious
Virulence factors
Immune evasion
