性激素在肠易激综合征发病中的相关机制研究进展

Research progress on the related mechanism of sex hormones in irritable bowel syndrome

肠易激综合征(IBS)是最常见的功能性胃肠道疾病,其发病呈现出明显的性别差异,女性患病率高于男性,且该疾病的临床特征也呈现出一定的性别差异。IBS患者的雌激素和雄激素水平与健康对照者之间存在着明显的差异,这提示男女的性别差异、性激素水平及其生物学效应的差异可能在IBS发病中起着重要作用。因此,该文系统综述了性激素与IBS发病的相关性,及其在IBS发病中的相关机制的研究进展,旨在为解释IBS的发病规律及探索新的治疗策略提供新思路。

Irritable bowel syndrome(IBS) is the most common functional gastrointestinal disease, and its incidence shows obvious gender differences.The incidence of IBS in females is higher than that in males, and the clinical characteristics of IBS also show some gender differences.The levels of estrogen and androgen in patients with IBS are significantly different from those in healthy controls, which suggests that gender differences, sex hormone levels and their biological effects between men and women may play an important role in the pathogenesis of IBS.Therefore, the review systematically reviews the correlation between sex hormones and the pathogenesis of IBS,and the research progress of its related mechanism in IBS,in order to provide new ideas for explaining the pathogenesis of IBS and exploring new therapeutic strategies.