摘要
特发性肺纤维化(IPF)是一种能导致肺功能进行性损伤的间质性肺疾病。目前病因尚不明确,DNA损伤修复在IPF的发病机制中可能起着重要作用。细胞受到外界刺激导致DNA损伤时,DNA修复蛋白被激活并发挥修复功能,其过程主要由多聚二磷酸腺苷核糖聚合酶-1及多种细胞因子介导,最终使受损DNA得到修复。该文就DNA损伤修复与IPF关系的研究进展进行综述。
Idiopathic pulmonary fibrosis(IPF) is an interstitial lung disease that can cause progressive damage to lung function.At present, the etiology is still unclear, and DNA damage repair may play an important role in the pathogenesis of IPF.When cells are damaged by external stimuli, DNA repair proteins are activated and play the repair function.The process is mainly mediated by poly(ADP-ribose) polymerase-1 and various cytokines, and finally the damaged DNA is repaired.The article reviews the research progress of the relationship between DNA damage repair and IPF.
作者
李永霞(综述)
江宇(审校)
LI Yongxia;JIANG Yu(Department of Respiratory,University-Town Hospital of Chongqing Medical University,Chongqing 401331,China)
出处
《现代医药卫生》
2023年第3期477-481,共5页
Journal of Modern Medicine & Health
基金
重庆市自然科学基金面上项目(cstc2020jcyj-msxmX0359)。
关键词
DNA损伤修复
特发性肺纤维化
关系研究
PARP-1
NF-ΚB
TGF-Β1
DNA damage repair
Idiopathic pulmonary fibrosis
Relationship research
Poly(ADP-ribose)polymerase-1
Nuclear factor kappa-B
Transforming growth facter-β1
