滇重楼化学成分、药理作用和临床应用研究进展

Research progress on chemical constituents,pharmacological actities,and clinical applications of Paris polyphylla var.yunnanensis

滇重楼Parispolyphyllavar.yunnanensis是临床常用的清热解毒药,具有清热解毒、消肿止痛、凉肝定惊功效,在临床实践中有广泛应用。目前从滇重楼中分离鉴定出的化学成分共125种,按照结构类型的差异可分为甾体皂苷类(72种)、C21甾体类(6种)、五环三萜类(19种)、植物甾醇类(3种)、黄酮类(7种)和其他化合物(18种),具有抗肿瘤、抑菌、抗氧化、镇痛、止血等活性。根据国内外文献报道,总结并综述了滇重楼的化学成分、药理作用和临床应用3方面的研究进展,以期为滇重楼资源的开发及临床合理应用提供参考。

Dianchonglou(Paris polyphylla var.yunnanensis) was a commonly used clinical medicine for clearing heat and detoxification,relieving swelling and pain,cooling the liver and relieving convulsion.At present,a total of 125 chemical components have been isolated and identified from P.polyphylla var.yunnanensis,which can be divided into 72 saponins,6C21 steroids,19 terpenoids,3 phytosterols,7 flavonoids,and 18 other compounds according to the differences in structure types,with antitumor,antibacterial,antioxidant,analgesic,hemostatic and other active effects.According to the domestic and foreign relevant literature,this paper reviews the research status on the chemical constituents,pharmacological actions,and clinical applications of P.polyphylla var.yunnanensis,in the expectation of providing references for the further development and rational utilization of this plant resource.