基于社区病毒载量分析HIV传播潜力社区

Analysis of potential HIV transmission community based on community viral load

目的基于ArcGIS地理可视化验证社区病毒载量(CVL)衡量特定地理区域内HIV的传播潜力的效用并分析具有HIV传播潜力的重点社区。方法收集2019年新疆某市13岁以上HIV/AIDS患者数据,通过线性相关和线性回归分析CVL与HIV传播潜力相关指标的关联性,并运用地理可视化描述不同社区不同人群CVL地理分布情况。结果CVL与未抑制率、病毒血症流行率、未治率呈正相关(P<0.05);线性回归分析显示CVL与病毒血症流行率关联性最强(AIC/BIC:-18.82/-15.69,P<0.001)。多项指标指示8号(CVL:2.25log_(10)copies/mL)、9号(CVL:2.18log_(10)copies/mL)、19号(CVL:2.09log_(10)copies/mL)研究标定社区高于全市水平(1.92log_(10)copies/mL)为重点社区。CVL与病毒血症流行率全局趋势走向一致,地理可视化描述中全人群CVL与可检测者CVL重点社区(8号、9号、19号社区)分布一致。结论CVL结合地理信息可精准定位具有HIV传播潜力的重点社区,应对该市8号、9号、19号重点社区实施针对性干预措施。

Objective To measure the effectiveness of HIV transmission potential in specific geographical areas and to analyze HIV key communities based on ArcGIS geographic visualization verification community viral load(CVL).Methods We collected HIV/AIDS data among people aged 13 years old and above in a city in Xinjiang in 2019.The association between CVL and HIV transmission potential-related indicators was analyzed through linear correlation,linear regression.Visualized the geographical distribution of CVL was used to describe CVL in different communities and different populations.Results CVL was positively correlated with unsuppressed rate,viremia prevalence,and untreated rate(P<0.05).The linear regression analysis showed that CVL had the strongest correlation with viremia prevalence(AIC/BIC:-18.82/-15.69,P<0.001).Several factors indicated that the No 8(CVL:2.25log_(10)copies/mL),the No 9(CVL:2.18log_(10)copies/mL),and the No 19(CVL:2.09log_(10)copies/mL)research-calibrated communities were defined as the key communities since their CVLs were higher than the city average level(1.92log_(10)copies/mL).The trend of CVL and viremia prevalence was consistent with each other and the distribution of CVL and detectable CVL key communities(Community 8,9,19)in the geographic visualization description was consistent.Conclusions Combined with geographic regions,CVL can accurately locate HIV key communities.Tailored intervention measures should be implemented in the city’s No.8,9,and 19 key communities.