摘要
姜黄素是提取于姜科姜黄属植物姜黄Curcuma longa、温郁金C.wenyujin等根茎中的多酚类化合物,具有抗炎、抗肿瘤等药理作用。研究表明姜黄素对结肠癌发生、发展的多个阶段具有预防作用和显著的治疗作用。姜黄素可通过抑制结肠炎症、抑制结肠癌细胞增殖、诱导凋亡、抑制侵袭转移和化疗耐药性等发挥抗结肠癌的作用。主要综述了姜黄素对炎性驱动结肠癌的早期预防作用、结肠癌细胞的治疗作用和相关信号通路的调控作用,为姜黄素的进一步开发和临床应用提供参考。
Curcumin is a polyphenolic compound extracted from the rhizomes of Curcuma longa,C.wenyujin and other plants of the genus Curcuma in Zingiberaceae.It has anti-inflammatory,anti-tumor and other pharmacological effects.Studies have shown that curcumin has a preventive and significant therapeutic effect on the occurrence and development of colon cancer.Curcumin can play an anti-colon cancer role by inhibiting colon inflammation,inhibiting colon cancer cell proliferation,inducing apoptosis,inhibiting invasion and metastasis and chemotherapy resistance.The early prevention effect of curcumin on inflammatory colon cancer,the therapeutic effect of colon cancer cells and the regulation of related signaling pathways were mainly reviewed in this paper,which provided reference for the further development and clinical application of curcumin.
作者
刘婷
高飞云
张转红
王彦钧
张育贵
孙宇靖
李越峰
LIU Ting;GAO Fei-yun;ZHANG Zhuan-hong;WANG Yan-jun;ZHANG Yu-gui;SUN Yujing;LI Yue-feng(Gansu University of Chinese Medicine,Lanzhou 730000,China;Key Laboratory of Standard and Quality of Chinese Medicine Research of Gansu,Lanzhou 730000,China;Gansu Engineering Research Center for Chinese Medicine Pharmaceutical Technology,Lanzhou 730000,China)
出处
《中草药》
CAS
CSCD
北大核心
2022年第24期7933-7940,共8页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(81960713)
国家自然科学基金资助项目(82160750)
国家自然科学基金资助项目(81460611)
甘肃省教育厅产业支撑计划项目(2021CYZC-21)
甘肃省中药制药工艺工程研究中心开放课题(ZYGY202003)
甘肃省科技计划(创新基地与人才计划)基础研究创新群体项目(21JR7RA569)。
关键词
姜黄素
结肠癌
细胞增殖
诱导凋亡
侵袭转移
化疗耐药性
信号通路
curcumin
colon cancer
cell proliferation
inducing apoptosis
invasion and metastasis
chemotherapy resistance
signaling pathway
