摘要
In the present paper,we describe the first complex multifocal noninvasive morphological andfunctional study that enabled us to define specific qualitative and quantitative features of neo-natal skin.A complex morphofunctional examination of 10 infants aging from 1 to 28 days wasperformed by optical coherence tomography(OCT)device with a flexible probe at the wavelength of 920 nm with longitudinal resolution of 20μm and transverse resolution of 25μm with simultaneous measurement of skin functional parameters.The OCT images of neonatal thin skinhave organized layered structure with four horizontally oriented layers.Thick skin of newbornshas no structure typical for adult skin and no clear transition from the papillary to the cellulardermis.Thus,we show for the first time to our knowledge that neonatal thick skin differs structurally and functionally from adult skin.Structurally,it differs by a loose arrangement of stratum corneum squamae and thinner epidermis and papilary layer of dermis.The functionaldifferences are lower transepidermal water loss,localization-dependent humidity,higher ery,thema level,and lower pigmentation.The principal structural diferences between neonatal andadult skin show that skin structure formation is not completed by the moment of birth.
基金
supported by the Ministry of Educationand Science of Russian Federation(project 8741)
RFBR(project 13-02-97092).
