Anti-tumor activities of a novel chlorin derivative for photodynamic therapy in vitro and in vivo

In this study,a novel photosensitizer mesc-tetra(3-prrolidinomethyl-4-methoxyphenyl)chlorin(TPMC)was reported.It displays a characteristic long wavelength absorption peak at 656 nm and it shows a singlet oxygen quantum yield of 0.48.After light iradiation with 650 nm laser,it can kill Eca-109 and SMMC-7721 cells in vitro(25 mW/cm^(2),1.2 to 3.6J/cm^(2))and destroy Eca-109 tumor in nude mice(50 mW/cm^(2),90J/cm^(2)).It has the perspective to be developed as a new anti-tumor drug in photodynamic therapy(PDT)photodiagnosis,and deserves further investigation.