Tumor therapy by fast moving magnetic nanoparticle under low-frequency alternating magnetic field

Magnetic nanoparticle plays an important role in biomedical engineering,especially in tumor therapy.In this paper,a new technique has been developed by using the rapid moving magnetic nanoparticle under a low-fequency alternating magnetic field(LFAMF)to kill tumor cells.The LFAMF system which was used to drive magnetic nanoparticles(MNPs)was setup with the magnetic field frequency and power range at心10-100Hz and~10-200 mT,respectively.During the experiment,the LFAMF was adjusted at different frequencies and power levels.The exper-imental results show that the liver tumnor cells(HepG2)mixed with MNPs(10 pug/mL)becamne partial fragments when exposed in the LFAMF with different frequencies(~10-100Hz)and power(~10200 mT),and the higher the frequency or the power,the more the tumor cells were killed at the same magnetic nanoparticle concentration.Conclusion:Tumor oells were effectively damaged by MNPs under LFAMF,which suggests that they had great potential to be applied in tumor therapy.