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Change of photosensitizer fluorescence at its diffusion in viscous liquid flow

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摘要 In this paper,the mathematical model of distribution of the injected compound in biological liquid flow has been described.It is considered that biological liquid contains a few phases such as water,peptides and cells.The injected compound(for example,photosensitizer)can interact with peptides and cells.At the time,viscosity of the biological liquid depends on pathology present in organism.The obtained distribution of the compound connects on changes of its fluorescence spectra which are registered during fluorescent diagnostics of tumors.It is obtained that the curves do not have monotonic nature.There is a sharp curves decline in the first few seconds after injection.Intensivity of curves rises after decreasing.It is especially pronounced for wavelength 590 nm and 580 nm(near the"transparency window"of biological tissues).Time of inflection point shifts from 8.4 s to 6.9 s for longer wavelength.However,difference between curves is little for di®erent viscosity means of the biological liquid.Thus,additional pathology present in organism does not impact to the results of in vivo biomedical investigations.
出处 《Journal of Innovative Optical Health Sciences》 SCIE EI CAS 2016年第2期25-30,共6页 创新光学健康科学杂志(英文)
基金 The work was supported by RFBR grant 14-01-31081 mol a and president scholarship SP-273.2015.4.
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