中青年阻塞性睡眠呼吸暂停综合征与缺血性脑卒中相关性分析

Analysis of the Correlation between Obstructive Sleep Apnea Syndrome and Ischemic Stroke in Middle-aged and Young Adults

目的:分析中青年阻塞性睡眠呼吸暂停综合征(OSAS)与缺血性脑卒中(IS)的相关性。方法:选取2020年月1月-2021年12月溧阳市人民医院神经内科收治的IS患者42例为研究1组;选取同期收治的IS伴发OSAS患者42例为研究2组;选取同期体检健康人员42例为对照组。检测相关指标,比较三组血脂指标[高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、胆固醇(TC)]及血尿酸(UA)水平、肺功能指标[用力肺活量(FVC)、1s用力呼气容积(FEV_(1))、一秒率(FEV_(1)/FVC)],分析LDL-C、TG、UA与FEV_(1)/FVC相关性,分析LDL-C、TG、UA与IS伴发OSAS的相关性。结果:研究2组患者LDL-C、TG、UA水平高于研究1组、对照组,差异有统计学意义(P<0.05);研究2组患者FVC、FEV_(1)、FEV_(1)/FVC水平低于研究1组、对照组,差异有统计学意义(P<0.05);Pearson相关性分析表明LDL-C、TG、UA与FEV_(1)/FVC呈负相关,差异有统计学意义(r=0.617、0.623、0.615,P<0.05);Logistic回归性分析表明IS伴发OSAS的独立影响因素为LDL-C、TG及UA水平上升,差异有统计学意义(P<0.05)。结论:IS患者存在肺功能抑制,LDL-C、TG、UA水平异常,IS伴OSAS的独立影响因素为LDL-C、TG及UA水平上升,OSAS可进一步加重IS患者病情,影响预后。

Objective:To analyze the correlation between obstructive sleep apnea syndrome(OSAS)and ischemic stroke(IS)in young and middle-aged people.Methods:Forty-two cases of IS patients admitted to the Department of Neurology of Liyang People's Hospital from January 2020 to December 2021 were selected as study group 1.Forty-two cases of IS with OSAS admitted in the same period were selected as study group 2.Forty-two cases of healthy personnel with physical examination in the same period were selected as the control group.Relevant indexes were measured,and the lipid indexes[high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),triglyceride(TG),cholesterol(TC)]and blood uric acid(UA)levels,pulmonary function indexes[exertional spirometry(FVC),1 s exertional expiratory volume(FEV_(1)),forced expiratory volume in one second/forced vital capacity(FEV_(1)/FVC)]were compared among the three groups,and LDL-C,TG,UA and FEV_(1)/FVC were analyzed.The correlation between LDL-C,TG,UA and IS with OSAS was analyzed.Results:The levels of LDL-C,TG,and UA were higher in study group 2 patients than in study group 1 and control group,and the differences were statistically significant(P<0.05).The levels of FVC,FEV_(1),and FEV_(1)/FVC in patients in study group 2 were lower than those in study group 1 and control group,and the difference was statistically significant(P<0.05).Pearson correlation analysis showed that LDL-C,TG,and UA were negatively correlated with FEV_(1)/FVC,and the difference was statistically significant(r=0.617,0.623,0.615,P<0.05).Logistic regression analysis showed that the independent influencing factors for IS with OSAS were increased levels of LDL-C,TG and UA,and the difference was statistically significant(P<0.05).Conclusion:Patients with IS have suppressed pulmonary function and abnormal LDL-C,TG,and UA levels,and the independent influencing factors for IS with OSAS are increased LDL-C,TG,and UA levels,and OSAS can further aggravate the condition of patients with IS and affect the prognosis.