黄芪止泻合剂联合益生菌补剂对轮状病毒性肠炎患儿肠道激素及免疫功能的影响

Effect of Astragalus Antidiarrheal Combination with Probiotic Supplementation on Intestinal Hormone and Immune Function in Children with Rotavirus Enteritis

目的:探讨黄芪止泻合剂联合益生菌补剂对轮状病毒性肠炎患儿肠道激素及免疫功能的影响。方法:选取2020年5月-2022年4月河南省台前县妇幼保健计划生育服务中心收治的轮状病毒性肠炎患儿106例为观察对象,按照随机数字表法分为联合组和对照组,各53例。对照组给予益生菌补剂治疗,联合组在对照组基础上联合黄芪止泻合剂治疗,比较两组患者临床疗效、中医证候积分、肠道激素[促胃液素(GAS)、胃动素(MOT)、血管活性肠肽(VIP)]、免疫功能[免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、CD4^(+)/CD8^(+)]、不良反应发生率。结果:联合组治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗后,两组患儿大便稀溏、食欲减退、面色萎黄评分均将低,联合组低于对照组,差异有统计学意义(P<0.05);治疗后,两组患儿GAS、MOT、VIP水平均降低,联合组低于对照组,差异有统计学意义(P<0.05);治疗后,两组患儿IgG、IgA、CD4^(+)/CD8^(+)水平均提高,联合组高于对照组,差异有统计学意义(P<0.05);两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论:黄芪止泻合剂联合益生菌补剂治疗轮状病毒性肠炎患儿能有效提高临床疗效,改善相关症状,调节胃肠激素及免疫功能,安全性良好。

Objective:To investigate the effects of astragalus antidiarrheal combination with probiotic supplementation on intestinal hormone and immune function in children with rotavirus enteritis.Methods:106 cases of children with rotavirus enteritis admitted to the Women and Children Health and Family Planning Service Center of Taiqian County,Henan Province,from May 2020 to April 2022 were selected as observation subjects.According to the random number table method,they were divided into combined group and control group,53 cases each.The control group was treated with probiotic supplementation,and the combined group was treated with astragalus antidiarrheal combination on the basis of the control group.The clinical efficacy,TCM syndrome score,intestinal hormones[gastrin(GAS),gastrin(MOT),vasoactive intestinal peptide(VIP)],immune function[immunoglobulin G(IgG),immunoglobulin A(IgA),CD4^(+)/CD8^(+)],and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the combined group was higher than that in the control group,and the difference was statistically significant(P<0.05);after treatment,the scores of loose stools,loss of appetite,and atrophy of the children in both groups would be lower,and the difference was statistically significant(P<0.05)in the combined group than that in the control group.After treatment,the GAS,MOT and VIP levels of children in both groups were reduced,and the difference was statistically significant(P<0.05)in the combined group compared with the control group.After treatment,IgG,IgA,CD4^(+)/CD8^(+)levels increased in both groups,and the combined group was higher than the control group,and the difference was statistically significant(P<0.05);the difference was not statistically significant when comparing the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Astragalus antidiarrheal compound combined with probiotic supplementation can effectively improve clinical efficacy,improve related symptoms,regulate gastrointestinal hormone and immune function in children with rotavirus enteritis with good safety.