摘要
线粒体是人体内重要的细胞器,它在细胞供能、调节细胞凋亡、钙信号和活性氧的管理中发挥着重要作用。近几年来,线粒体研究在辅助生殖领域中越来越多,多数研究是关于卵母细胞的发育、卵巢储备功能等,而线粒体在卵丘颗粒细胞及体外胚胎培养液中的研究较少。卵丘颗粒细胞线粒体在预测胚胎质量及妊娠结局方面的作用仍没有明确定论,胚胎培养液中的线粒体能否预测胚胎发育潜能尚需进一步研究,本文就此热点展开综述,以期为临床研究提供最新理论依据。
Mitochondria is an important organelle in human body,which plays an important role in many cells’energy production,regulation of apoptosis,calcium signal and management of reactive oxygen species.In recent years,more and more studies on mitochondria have been done in assisted reproduction field,and most of them are related to oocyte development and ovarian reserve.However,there were few studies on cumulus granulosa cells and in vitro embryo culture medium.There is still no definite conclusion on the prediction of embryo quality and pregnancy outcome by mitochondria of cumulus granulosa cells.Whether mitochondria of embryo culture medium can predict embryo development potential needs further study.This paper reviews the hot spot to provide the latest theoretical basis for clinical research.
作者
甄雪蓉
贾俊龙
王玲
ZHEN Xue-rong;JIA Jun-long;WANG Ling(First Clinical Medical School,Gansu University of Chinese Medicine,Lanzhou 730000;Reproductive Medicine Centre,the 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation Army,Lanzhou 730050)
出处
《生殖医学杂志》
CAS
2023年第2期301-304,共4页
Journal of Reproductive Medicine
基金
兰州市科技局市级课题(2021-1-100)
联勤保障部队战勤部面上项目(CLB19J048)。
关键词
线粒体
卵丘颗粒细胞
胚胎培养液
研究进展
Mitochondria
Cumulus granulosa cells
Embryo culture medium
Research progress