摘要
体液中的微小RNA(miRNA)采集方便,创伤性小,具有作为颅内动脉瘤(IA)生物标志物的潜力,适合于IA的早期筛查与破裂预测。稳定存在于血清、血浆等体液中的miRNA(即循环miRNA)参与调控血管平滑肌细胞和内皮细胞功能,在IA发生与进展的病理生理过程中发挥重要作用。本文现围绕循环miRNA作为生物标志物在IA早期诊断、破裂预测及预后评估中的研究现况综述如下。
Micro RNAs in body fluids,enjoying convenient collection and less invasion,have the potential of being biomarkers of intracranial aneurysm(IA),and are suitable for early screening and rupture prediction of IA.The stable micro-RNAs(circulating micro RNAs)in serum,plasma and other body fluids are involved in regulating the functions of vascular smooth muscle cells and endothelial cells,and play important roles in pathophysiological process of IA progression.In this paper,the current research progress of circulating micro RNAs as biomarkers in the early diagnosis,rupture prediction and prognoses of IA are summarized as follows.
作者
朱艺琳
刘嘉棋
田昊
孙海涛
Zhu Yilin;Liu Jiaqi;Tian Hao;Sun Haitao(Second Clinical Medical College,Southern Medical University,Guangzhou 510282,China;Neurosurgery Center,National Key Clinical Specialty,Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Diseases,Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration,Neurosurgery Institute of Guangdong Province,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China;Clinical Biological Sample Resource Center of Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2022年第12期1269-1275,共7页
Chinese Journal of Neuromedicine
基金
广东省基础与应用基础研究基金(2020A1515010038)
南方医科大学珠江医院院长基金(yzjj2018rc03)
大学生创新创业项目(S202112121058)。
