纳米技术在糖尿病视网膜病变诊断和治疗中的应用

Application of nanotechnology on diagnosis and treatment of diabetic retinopathy

纳米技术可以利用纳米颗粒的特殊性质对纳米粒子表面进行修饰。采用该技术合成的聚乙烯亚胺修饰的荧光素钠纳米颗粒既可以保留荧光素钠用于视网膜脉络膜疾病诊断的光学性能,又较游离荧光素钠拥有更快的代谢速率,从而安全有效诊断糖尿病视网膜病变(diabetic retinopathy,DR);钒核壳纳米棒辅助激光解吸/电离质谱的方法获得的血浆代谢指纹图谱可以用于DR进展监测。将药物封装在纳米粒子内,可以形成靶向可控释放、易于检测的药物运输载体,为治疗DR提供新的思路。

Nanotechnology can use the special properties of nanoparticles to modify the surface of nanoparticles,which was used to produce sodium fluorescein modified with polyvinyl imine nanoparticles(PEI-NHAc-FS NP),can not only retain the optical properties of sodium fluorescein for the diagnosis of retinal and choroidal diseases,but also have a faster metabolic rate than free sodium fluorescein,so as to safely and effectively diagnose diabetes retinopathy(DR).The progress of DR can be monitored by detecting the metabolic characteristics of plasma by vanadium core-shell nanorods assisted laser desorption/ionization mass spectrometry.Encapsulated drugs in nanoparticles can form drug delivery carriers with targeted,controlled release and easy detection,which provides a new idea for the treatment of DR.