高原环境对肾功能影响的meta分析

Effects of high altitude environment on renal function: a meta-analysis

目的 通过meta分析研究高原环境对人肾功能的影响。方法 检索中国知网(CNKI)、维普、万方、Web of Science、PubMed、Embase数据库,检索时间为建库至2021年11月15日。由2名研究者完成文献的筛选和相关信息的提取。使用Stata 15、RevMan 5.3软件对提取的数据进行统计学处理,采用敏感性分析的方法对所纳入研究的数据质量进行评价。结果 共纳入7篇文章,681例研究对象。结果显示,高原低氧环境对尿素氮(MD=-0.58,95%CI=-1.08~-0.08)、尿酸(MD=83.84,95%CI=77.24~90.44)、尿微量蛋白水平(MD=5.85,95%CI=5.32~6.39)、肾小球滤过率(MD=-7.75,95%CI=-10.42~-5.08)、血清肌酐(MD=16.34,95%CI=15.06~17.61)具有相关性影响。结论 高原低氧环境会对肾功能产生不利影响。

Objective To study the effect of high altitude environment on human renal function through meta-analysis.Methods The databases of China National Knowledge Infrastructure(CNKI),VIP,Wanfang, Web of Science, PubMed, and Embase were searched, and the search time was limited from the establishment of the databases to November 15,2021.Literature screening and relevant information extraction were completed by two researchers.The extracted data were statistically analyzed using Stata 15 and RevMan 5.3 software, and the quality of the included studies was evaluated by sensitivity analysis.Results A total of seven articles and 681 subjects were included in this study.The results showed that high altitude hypoxic environment had a correlation effect on blood urea nitrogen(MD=-0.58,95%CI=-1.08--0.08),uric acid(MD=83.84,95%CI=77.24-90.44),urinary microprotein levels(MD=5.85,95%CI=5.32-6.39),glomerular filtration rate(MD=-7.75,95%CI=-10.42--5.08),and serum creatinine(MD=16.34,95%CI=15.06-17.61).Conclusion High altitude hypoxic environment can adversely affect renal function.