摘要
干扰素-γ是调节机体免疫的重要细胞因子,在肿瘤发生与进展中发挥关键作用。干扰素-γ在口腔鳞状细胞癌的发展中存在着复杂的作用机制。在肿瘤微环境中,干扰素-γ能在不同细胞间进行表达,从而发挥不同功能并受到明显调控。以往认为干扰素-γ始终发挥肿瘤抑制作用,但最新研究发现其可能会促进口腔鳞状细胞癌的进展。该文对目前干扰素-γ在口腔鳞状细胞癌组织中的表达及功能进行了综述。
Interferon-γ(IFN-γ) is an important cytokine that regulates the body’s immunity and plays a key role in the occurrence and progression of tumors.IFN-γ has a complex mechanism of action in the development of oral squamous cell carcinoma.In the tumor microenvironment, IFN-γ can be expressed in different cells, and thus play different functions and be regulated significantly.In the past, it was thought that IFN-γ was previously thought to have always played a tumor suppressor role, but the latest research has found that it may promote the progression of oral squamous cell carcinoma.This article reviewed the current expression and function of IFN-γ in oral squamous cell carcinoma.
作者
丁天皓
廖成成(综述)
李萍
李小兰(审校)
DING Tianhao;LIAO Chengcheng;LI Ping;LI Xiaolan(Affiliated Stomatology Hospital of Zunyi Medical University,Zunyi,Guizhou 563000,China;Special Key Laboratory of Oral Diseases Research,Higher Education in Guizhou Province,Zunyi,Guizhou 563000,China)
出处
《重庆医学》
CAS
2023年第3期446-450,共5页
Chongqing medicine
基金
贵州省中医药管理局中医药、民族医药科学技术研究课题(QZYY-2019-064)
遵义医科大学2018年度学术新苗培养及创新探索专项项目(黔科合平台人才[2018]5772-075)。
关键词
干扰素-Γ
口腔鳞状细胞癌
免疫调节
肿瘤微环境
免疫细胞
综述
interferon-γ
oral squamous cell carcinoma
immunomodulation
tumor microenvironment
immune cells
review
