动物继承牙发育调控机制研究进展

Research progress in the regulatory mechanism of animal successional tooth development

牙齿的发育涉及口腔上皮和间充质之间的相互作用,并通过复杂的调控网络来实现。牙齿发育调控分子的时空表达异常可能会导致牙齿发育起始和继承牙更替异常,进而影响牙齿数量,造成牙缺失和多生牙等。除了利用传统的小鼠模型,近年来,小型猪、猴子、雪貂等动物也越来越多的应用于牙齿发育研究。本文主要概述了脊椎动物继承牙发育的模型和分子调控网络,以期系统地理解人类牙齿数量异常疾病的成因。

Tooth development involves reciprocal interactions between oral epithelium and mesenchyme,and is achieved through complex regulatory networks.Abnormal spatiotemporal expression of the molecules involved in regulating tooth development may lead to abnormities of tooth development initiation and successional tooth replacement,which in turn affect the number of teeth,resulting in tooth agenesis and hyperplasia.In addition to using traditional mouse models,in recent years,animals such as miniature pigs,monkeys,and ferrets have been increasingly used in tooth development research.Here,we summarize tooth development models and molecular regulatory networks of vertebrate successional teeth to systematically understand the causes of abnormalities of the tooth number in humans.