新诊断的老年男性2型糖尿病患者血尿酸水平与骨质疏松的相关性

Correlation between Serum Uric acid Level and Osteoporosis in Newly Diagnosed Elderly Male Patients with Type 2 Diabetes

[目的]探讨新诊断的老年男性2型糖尿病患者血尿酸水平与骨质疏松的相关性.[方法]选取2020年3月至2022年7月在本院就诊且新诊断的200例老年男性2型糖尿病患者,使用双能X线骨密度仪检测所有患者各部位骨密度(BMD)值,依据患者BMD值分为非骨质疏松组(n=144)和骨质疏松组(n=56).收集患者年龄、体重指数(BMI)、血尿酸等指标,分析各项指标与BMD值的相关性.[结果]与非骨质疏松组相比,骨质疏松组患者BMI、血尿酸、四肢骨骼肌质量(ASM)、四肢骨骼肌质量指数(ASMI)、各部位BMD值较低(P<0.05).BMI、血尿酸、ASM、ASMI与各部位BMD呈正相关(P<0.05).多元Logistic回归分析结果显示:低BMI、低ASMI是新诊断的老年男性2型糖尿病患者发生骨质疏松的独立危险因素,血尿酸是保护因素(P=0.0171).[结论]新诊断的老年男性2型糖尿病患者血尿酸维持在正常或稍高水平可有效预防患者发生骨质疏松,可将血尿酸作为筛选骨质疏松患者的一项重要指标.

【Objective】To investigate the correlation between serum uric acid level and osteoporosis in newly diagnosed elderly male type 2 diabetes patients.【Methods】A total of 200 elderly male patients with type 2 diabetes who were newly diagnosed in our hospital from March 2020 to July 2022 were selected.The bone mineral density(BMD)values of all patients were measured by dual energy X-ray absorptiometry.According to the BMD values of patients,they were divided into non osteoporosis group(n=144)and osteoporosis group(n=56).The age,body mass index(BMI),blood uric acid and other indicators of patients were collected,and the correlation between each indicator and BMD value was analyzed.【Results】Compared with the non osteoporosis group,the patients in the osteoporosis group had lower BMI,blood uric acid,limb skeletal muscle mass index(ASM),limb skeletal muscle mass index(ASMI),and BMD values of each part(P<0.05).BMI,blood uric acid,ASM,and ASMI were positively correlated with BMD of each site(P<0.05).Multiple logistic regression analysis showed that low BMI and low ASMI were independent risk factors for osteoporosis in newly diagnosed elderly male patients with type 2 diabetes,and serum uric acid was a protective factor(P=0.0171).【Conclusion】The newly diagnosed elderly male type 2 diabetes patients with normal or slightly higher levels of blood uric acid can effectively prevent osteoporosis,and blood uric acid can be used as an important indicator for screening osteoporosis patients.