血清骨膜蛋白、透明质酸与急性自发性脑出血预后的相关性研究

Correlation between Serum Periosteal Protein,Hyaluronic Acid and Prognosis of Acute Spontaneous Intracerebral Hemorrhage

[目的]探讨血清骨膜蛋白、透明质酸与急性自发性脑出血(ASICH)预后的关系.[方法]选取89例ASICH患者(观察组)和44例健康体检者(对照组)作为研究对象,检测两组血清骨膜蛋白、透明质酸水平.采用Pearson分析骨膜蛋白和透明质酸与美国国立卫生研究院卒中量表(NIHSS)评分、血肿体积及改良Rankin评分量表(mRS)评分的相关性,采用Logistic回归分析ASICH预后的风险因素,用受试者工作特征(ROC)曲线评价骨膜蛋白、透明质酸预测ASICH预后的价值.[结果]观察组骨膜蛋白、透明质酸水平均高于对照组(P<0.05).骨膜蛋白和透明质酸与NIHSS评分、血肿体积及mRS评分均呈正相关.Logistic回归分析结果显示,年龄>65岁、NIHSS评分>12分、出血体积>28 mL、早期神经功能恶化、骨膜蛋白>287.78 ng/mL和透明质酸>593.92 ng/mL均是影响ASICH预后的独立危险因素.血清骨膜蛋白、透明质酸评估ASICH患者预后价值较高.[结论]血清骨膜蛋白和透明质酸水平高提示ASICH患者病情严重,患者预后不良风险增加.

【Objective】To investigate the relationship between serum periosteal protein,hyaluronic acid and the prognosis of acute spontaneous intracerebral hemorrhage(ASICH).【Methods】A total of 89 patients with ASICH(observation group)and 44 healthy people(control group)were selected as the study objects,and the levels of serum periosteal protein and hyaluronic acid were measured.Pearson was used to analyze the correlation between periosteal protein and hyaluronic acid and NIHSS score,hematoma volume and mRS score.Logistic regression was used to analyze the risk factors of ASICH prognosis,and receiver operating characteristic(ROC)curve was used to evaluate the value of periosteal protein and hyaluronic acid in judging ASICH prognosis.【Results】The levels of periosteal protein and hyaluronic acid in the observation group were higher than those in the control group(P<0.05).Periosteal protein and hyaluronic acid were positively correlated with NIHSS score,hematoma volume and mRS score.Logistic regression analysis showed that age>65,NIHSS score>12,bleeding volume>28 mL,early neurological deterioration,periosteal protein>287.78 ng/mL and hyaluronic acid>593.92 ng/mL were all independent risk factors for the prognosis of ASICH.Serum periosteal protein and hyaluronic acid have high prognostic value in patients with ASICH.【Conclusion】The high levels of serum periosteal protein and hyaluronic acid suggest that patients with ASICH are in serious condition and have an increased risk of poor prognosis.